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TranHung
12:27 17/03/2026

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027688.2 RefSeqGene

    Range 5002..36273 Download GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000616.5 → NP_000607.1 T-cell surface glycoprotein CD4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_000607.1

    Status: REVIEWED

    Description Transcript Variant: This variant (1) encodes the longest isoform (1) including a signal peptide and a mature peptide. Source sequence(s) AC125494, U47924 Consensus CDS CCDS8562.1 UniProtKB/Swiss-Prot B2R737, D3DUS5, P01730, Q4ZGK2, Q5U066, Q9UDE5 UniProtKB/TrEMBL A0A4Y5UGE4 Related ENSP00000011653.4, ENST00000011653.9 Conserved Domains (5) summary pfam05790Location:317 → 389 C2-set; Immunoglobulin C2-set domain pfam09191Location:208 → 316 CD4-extracel; CD4, extracellular cd07690Location:26 → 122 IgV_1_CD4; First immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the V-set of IgSF domains cd07694Location:123 → 204 IgC2_2_CD4; Second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the C2-set of IgSF domains cd07695Location:219 → 223 IgV_3_CD4; Ig strand B [structural motif]

  2. NM_001195014.3 → NP_001181943.1 T-cell surface glycoprotein CD4 isoform 2

    See identical proteins and their annotated locations for NP_001181943.1

    Status: REVIEWED

    Description Transcript Variant: This variant (2) uses an alternate splice site, lacks two consecutive exons and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1. Source sequence(s) AC125494, U47924 UniProtKB/TrEMBL B0AZV7 Conserved Domains (4) summary cd12087Location:209 → 249 TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases pfam05790Location:138 → 210 C2-set; Immunoglobulin C2-set domain pfam09191Location:29 → 137 CD4-extracel; CD4, extracellular pfam12104Location:247 → 274 Tcell_CD4_C; T cell CD4 receptor C terminal region

  3. NM_001195015.3 → NP_001181944.1 T-cell surface glycoprotein CD4 isoform 3

    See identical proteins and their annotated locations for NP_001181944.1

    Status: REVIEWED

    Description Transcript Variant: This variant (3) uses an alternate splice site, lacks two consecutive exons and initiates translation from a downstream, in-frame start codon, compared to variant 1. Variants 3, 4 and 5 encode isoform 3, which has a shorter N-terminus, compared to isoform 1. Source sequence(s) AC125494, U47924 UniProtKB/TrEMBL B4DT49, B4E1T0 Conserved Domains (3) summary pfam05790Location:44 → 116 C2-set; Immunoglobulin C2-set domain cd00096Location:7 → 12 Ig; Ig strand E [structural motif] cl11960Location:1 → 43 Ig; Immunoglobulin domain

  4. NM_001195016.3 → NP_001181945.1 T-cell surface glycoprotein CD4 isoform 3

    See identical proteins and their annotated locations for NP_001181945.1

    Status: REVIEWED

    Description Transcript Variant: This variant (4) lacks two consecutive exons and initiates translation from a downstream, in-frame start codon, compared to variant 1. Variants 3, 4 and 5 encode isoform 3, which has a shorter N-terminus, compared to isoform 1. Source sequence(s) AC125494, U47924 UniProtKB/TrEMBL B4DT49, B4E1T0 Conserved Domains (3) summary pfam05790Location:44 → 116 C2-set; Immunoglobulin C2-set domain cd00096Location:7 → 12 Ig; Ig strand E [structural motif] cl11960Location:1 → 43 Ig; Immunoglobulin domain

  5. NM_001195017.3 → NP_001181946.1 T-cell surface glycoprotein CD4 isoform 3

    See identical proteins and their annotated locations for NP_001181946.1

    Status: REVIEWED

    Description Transcript Variant: This variant (5) uses an alternate splice site, lacks two consecutive exons and initiates translation from a downstream, in-frame start codon, compared to variant 1. Variants 3, 4 and 5 encode isoform 3, which has a shorter N-terminus, compared to isoform 1. Source sequence(s) AC125494, U47924 UniProtKB/TrEMBL B4DT49, B4E1T0 Conserved Domains (3) summary pfam05790Location:44 → 116 C2-set; Immunoglobulin C2-set domain cd00096Location:7 → 12 Ig; Ig strand E [structural motif] cl11960Location:1 → 43 Ig; Immunoglobulin domain

  6. NM_001382705.1 → NP_001369634.1 T-cell surface glycoprotein CD4 isoform 3

    Status: REVIEWED

    Source sequence(s) AC125494, U47924 UniProtKB/TrEMBL B4DT49, B4E1T0 Conserved Domains (3) summary pfam05790Location:44 → 116 C2-set; Immunoglobulin C2-set domain cd00096Location:7 → 12 Ig; Ig strand E [structural motif] cl11960Location:1 → 43 Ig; Immunoglobulin domain

  7. NM_001382706.1 → NP_001369635.1 T-cell surface glycoprotein CD4 isoform 3

    Status: REVIEWED

    Source sequence(s) AC125494, U47924 UniProtKB/TrEMBL B4DT49, B4E1T0 Conserved Domains (3) summary pfam05790Location:44 → 116 C2-set; Immunoglobulin C2-set domain cd00096Location:7 → 12 Ig; Ig strand E [structural motif] cl11960Location:1 → 43 Ig; Immunoglobulin domain

  8. NM_001382707.1 → NP_001369636.1 T-cell surface glycoprotein CD4 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s) AC125494, U47924 Consensus CDS CCDS8562.1 UniProtKB/Swiss-Prot B2R737, D3DUS5, P01730, Q4ZGK2, Q5U066, Q9UDE5 UniProtKB/TrEMBL A0A4Y5UGE4 Conserved Domains (5) summary pfam05790Location:317 → 389 C2-set; Immunoglobulin C2-set domain pfam09191Location:208 → 316 CD4-extracel; CD4, extracellular cd07690Location:26 → 122 IgV_1_CD4; First immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the V-set of IgSF domains cd07694Location:123 → 204 IgC2_2_CD4; Second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the C2-set of IgSF domains cd07695Location:219 → 223 IgV_3_CD4; Ig strand B [structural motif]

  9. NM_001382714.1 → NP_001369643.1 T-cell surface glycoprotein CD4 isoform 4

    Status: REVIEWED

    Source sequence(s) AC125494, U47924 Related ENSP00000542118.1, ENST00000872059.1 Conserved Domains (7) summary cd12087Location:333 → 373 TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases pfam05790Location:262 → 334 C2-set; Immunoglobulin C2-set domain pfam09191Location:153 → 261 CD4-extracel; CD4, extracellular cd00096Location:14 → 17 Ig; Ig strand C" [structural motif] cd07694Location:68 → 149 IgC2_2_CD4; Second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the C2-set of IgSF domains cd07695Location:164 → 168 IgV_3_CD4; Ig strand B [structural motif] cl11960Location:14 → 67 Ig; Immunoglobulin domain