Gene

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

1. NG_011653.1 RefSeqGene

   Range 5001..10850 Download GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

1. NM_001030047.1 → NP_001025218.1 prostate-specific antigen isoform 3 preproprotein

   See identical proteins and their annotated locations for NP_001025218.1

   Status: REVIEWED

   Description Transcript Variant: This variant (3) uses an alternate splice site at the end of a coding exon, that causes a frameshift. The resulting isoform (3) is shorter and has a distinct C-terminus compared to isoform 1. Source sequence(s) AC011523, BC005307, M21896 Consensus CDS CCDS33083.1 UniProtKB/TrEMBL M0R294 Related ENSP00000353829.2, ENST00000360617.7 Conserved Domains (2) summary smart00020Location:24 → 209 Tryp_SPc; Trypsin-like serine protease cd00190Location:25 → 209 Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

2. NM_001030048.1 → NP_001025219.1 prostate-specific antigen isoform 4 preproprotein

   See identical proteins and their annotated locations for NP_001025219.1

   Status: REVIEWED

   Description Transcript Variant: This variant (4) uses an alternate in-frame splice site at the end of a coding exon. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1. Source sequence(s) AC011523, BC005307, BQ932072 Consensus CDS CCDS46155.1 UniProtKB/TrEMBL Q6LDS3 Related ENSP00000471155.1, ENST00000595952.5 Conserved Domains (2) summary smart00020Location:24 → 210 Tryp_SPc; Trypsin-like serine protease cd00190Location:25 → 213 Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

3. NM_001648.2 → NP_001639.1 prostate-specific antigen isoform 1 preproprotein

   See identical proteins and their annotated locations for NP_001639.1

   Status: REVIEWED

   Source sequence(s) X05332 Consensus CDS CCDS12807.1 UniProtKB/Swiss-Prot C9JXH3, G3V0H4, G3XAE3, P07288, Q15096, Q16272, Q86TG8, Q8IXI4 UniProtKB/TrEMBL Q546G3, Q6LDS3 Related ENSP00000314151.1, ENST00000326003.7 Conserved Domains (1) summary cd00190Location:25 → 256 Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...